亚洲午夜视频-黄色三极片-亚色视频-一区二区网站-9.1人网站免费-久久久久国产一区二区三区潘金莲-亚洲成人日韩-五月伊人婷婷-久久国产精品99久久人人澡-色悠悠在线视频-波多野结衣家庭教师6-精品无码黑人又粗又大又长-桃花久久-亚洲第一男人天堂-伊人精品一区二区三区-玖玖综合网-国产大片中文字幕-日韩黄色精品视频-蜜桃视频在线观看网站-国产美女精品人人做人人爽-97香蕉久久夜色精品国产-国产激情99-无遮挡在线-少妇又色又紧又大爽又刺激-a毛片大片-久久国产精品精品国产-正在播放亚洲一区-欧亚在线视频-明星换脸自慰喷潮-丝袜系列第一页

Activity Measured by its ability to induce IL6
secretion by NHDF human normal dermal fibroblasts.
The ED50 for this effect is typically 26
ng/mL.
Measured by its ability to induce IL6
secretion by NIH-3T3 mouse embryonic fibroblast cells. Yao, Z. et al. （1995） Immunity 3:811.
The ED50 for this effect is typically 1.57.5
ng/mL.
Endotoxin Level <1.0 EU per 1 μg of the protein by the LAL method.
Purity >97%, by SDSPAGE
under reducing conditions and visualized by silver stain.
Formulation Lyophilized from a 0.2 μm filtered solution in HCl. See Certificate of Analysis for details.
PREPARATION AND STORAGE
Reconstitution Reconstitute at 100 μg/mL in 4 mM HCI.
Shipping The product is shipped with polar packs. Upon receipt, store it immediay at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freezethaw
cycles.
l 12 months from date of receipt, 20
to 70
°C as supplied.
l 1 month, 2 to 8 °C under sterile conditions after reconstitution.
l 3 months, 20
to 70
°C under sterile conditions after reconstitution.
BACKGROUND
Interleukin 17 （also known as CTLA8）
is a T cellexpressed
pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of
herpesvirus Saimiri. cDNA clones encoding IL17
have been isolated from activated rat, mouse and human T cells. Human IL17
cDNA encodes a 155 amino acid （aa）
residue precursor protein with a 19 amino acid residue signal peptide that is cleaved to yield the 136 aa residue mature IL17
containing one potential Nlinked
glycosylation site. Both recombinant and natural IL17
have been shown to exist as disulfidelinked
homodimers. At the amino acid level, human IL17
shows 72% and
63% sequence identity with herpesvirus and rat IL17,
respectively. An IL17
specific mouse cell surface receptor （IL17
R） has been cloned. While the expression of
IL17
mRNA is restricted to activated T cells, the expression of mIL17
R mRNA has been detected in virtually all cells and tissues tested. IL17
exhibits multiple
biological activities on a variety of cells including the induction of IL6
and IL8
production in fibroblasts, the enhancement of surface expression of ICAM1
in
fibroblasts, activation of NFκB
and costimulation of T cell proliferation. The nonglycosylated,
E. coliexpressed
rhIL17
has been shown to be active on human as
well as mouse cell lines.
References:
1. Yao, Z. et al. （1995） J. Immunol. 155:5483.
2. Yao, Z. et al. （1995） Immunity 3:811.
3. Rouvier, E. et al. （1993） J. Immunol. 150:5445

上海力敏實(shí)業(yè)有限公司代理R&D產(chǎn)品，咨詢 
上海力敏實(shí)業(yè)有限公司代理R&D產(chǎn)品，咨詢