亚洲午夜视频-黄色三极片-亚色视频-一区二区网站-9.1人网站免费-久久久久国产一区二区三区潘金莲-亚洲成人日韩-五月伊人婷婷-久久国产精品99久久人人澡-色悠悠在线视频-波多野结衣家庭教师6-精品无码黑人又粗又大又长-桃花久久-亚洲第一男人天堂-伊人精品一区二区三区-玖玖综合网-国产大片中文字幕-日韩黄色精品视频-蜜桃视频在线观看网站-国产美女精品人人做人人爽-97香蕉久久夜色精品国产-国产激情99-无遮挡在线-少妇又色又紧又大爽又刺激-a毛片大片-久久国产精品精品国产-正在播放亚洲一区-欧亚在线视频-明星换脸自慰喷潮-丝袜系列第一页

抗泛素抗體Anti-Ubiquitin antibody [Ubi-1]

Description Mouse monoclonal [Ubi-1] to Ubiquitin
Host species Mouse
Specificity Ubi-1 was initially screened on ELISA of the immunogen, and subsequently tested on sections of Alzheimer brain. It was one of several
clones which stained neurofibrillary tangles in frozen sectioned material strongly and specifically. Subsequent studies indicated that Ubi-
1 is relatively insensitive to formalin fixation and so can be used on mildly fixed histological sections of human brain for studies of
Alzheimer's disease. Ubi-1 also recognizes other ubiquitinated inclusion bodies such as the Lewy bodies of Parkinson's disease and
the Pick bodies in Pick's disease. This antibody recognizes polyubiquitin chains much more strongly than monoubiquitinated molecules
or free ubiquitin. Specifically recognizes ubiquitinated cytoplasmic inclusion bodies.
Tested applications IHC-P, WB, ELISA, ICC/IF, IHC-Fr
Cross reactivity Reacts with
Mouse, Chicken, Cow, Human, Arabidopsis thaliana, Caenorhabditis elegans, Fruit fly （Drosophila melanogaster）
Immunogen Full length native protein （purified） conjugated to KLH by a Glutaraldehyde linker.
Target
Relevance Ubiquitin is a highly conserved protein of about 8.5 kDa molecular weight, which has an ATP dependent role in the targeting of proteins
for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C terminus of ubiquitin,
and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently
bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodies
are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of
Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease are all heavily ubiquitinated
and can be readily visualized with ubiquitin antibodies.
Cellular localization Cell Membrane, Cytoplasmic and Nuclear
Alternative names FLJ25987 antibody
MGC8385 antibody
Polyubiquitin B antibody
RPS 27A antibody
RPS27A antibody
UBA 52 antibody
UBA 80 antibody
UBA52 antibody
UBA80 antibody
UBB antibody
UBC antibody
UBCEP 1 antibody
UBCEP 2 antibody
UBCEP1 antibody
UBCEP2 antibody
Ubiquitin antibody
ubiquitin B antibody
Properties
Form Liquid
Storage instructions Store at +4°C short term （1-2 weeks）. Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

抗泛素抗體Anti-Ubiquitin antibody [Ubi-1] 反應(yīng)性有其他種屬的：人，小鼠，大鼠等等

上海力敏實(shí)業(yè)有限公司代理abcam產(chǎn)品，咨詢抗泛素抗體Anti-Ubiquitin antibody [Ubi-1]詳細(xì)產(chǎn)品信息